Handbook of Downstream Processing

This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants.

Handbook of Downstream Processing

Handbook of Downstream Processing

The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

More Books:

Handbook of Downstream Processing
Language: en
Pages: 720
Authors: E. Goldberg
Categories: Science
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products.
Handbook of Process Chromatography
Language: en
Pages: 382
Authors: Gunter Jagschies, Gail K. Sofer, Lars Hagel
Categories: Science
Type: BOOK - Published: 2007-12-08 - Publisher: Elsevier

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together
Downstream Processing of Natural Products
Language: en
Pages: 354
Authors: M. S. Verrall
Categories: Science
Type: BOOK - Published: 1996-08-06 - Publisher: Wiley-Blackwell

Natural Products, broadly defined as high value chemical entities derived from plants or microbial sources, have been known and exploited for many years. In recent years, as the need for higher potency and predictability of such products has increased, more sophisticated concentration and isolation procedures have been developed. With the
Handbook of Biogeneric Therapeutic Proteins
Language: en
Pages: 584
Authors: Sarfaraz K. Niazi
Categories: Medical
Type: BOOK - Published: 2002-08-15 - Publisher: CRC Press

More than 20 billion dollars worth of biopharmaceuticals are scheduled to go off-patent by 2006. Given the strong political impetus and the development of technological tools that can answer the questions regulatory authorities may raise, it is inevitable that the FDA and EMEA will allow biogeneric or biosimilar products. Even
Handbook of Petrochemical Processes
Language: en
Pages: 562
Authors: James G. Speight
Categories: Science
Type: BOOK - Published: 2019-06-13 - Publisher: CRC Press

The petrochemical industry is a scientific and engineering field that encompasses the production of a wide range of chemicals and polymers. The purpose of this book is not only to provide a follow-on to form the later chapters of the highly successful Chemistry and Technology of Petroleum 5th Edition but

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